Potassium Channel

KcsA

Potassium Channel

Related Products

Potassium channels are the most widely distributed type of ion channel and are found in virtually all living organisms. They form potassium-selective pores that span cell membranes. Potassium channels are found in most cell types and control a wide variety of cell functions. Potassium channels function to conduct potassium ions down their electrochemical gradient, doing so both rapidly and selectively. Biologically, these channels act to set or reset the resting potential in many cells. In excitable cells, such asneurons, the delayed counterflow of potassium ions shapes the action potential. By contributing to the regulation of the action potential duration in cardiac muscle, malfunction of potassium channels may cause life-threatening arrhythmias. Potassium channels may also be involved in maintaining vascular tone.

Potassium Channel Related Products (932)
Antibodies (6)
Related Compound Screening Libraries (1)

By Effects:	Controls (9) Inhibitors (573) Agonists (16) Antagonists (35) Activators (197) Modulators (31) Chemical (1)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-15209

Repaglinide	Antagonist	99.89%
Repaglinide is an insulin secretagogue for the treatment of type-2 diabetes mellitus.

HY-17001

Flupirtine Maleate	Activator	99.97%
Flupirtine Maleate is a brain penetrant, and orally bioavailable, non-opioid and centrally acting analgesic agent. Flupirtine Maleate is an indirect N-methyl-D-aspartate receptor (NMDAR) antagonist. Neuroprotective properties.

HY-N6778

Paxilline	Inhibitor	99.91%
Paxilline is an indole alkaloid mycotoxin derived from Penicillium paxilli, which effectively inhibits the BK channel through a channel-blocking mechanism. Paxilline also inhibits sarco/endoplasmic reticulum Ca²⁺-stimulated ATPase (SERCA), with IC₅₀ values ranging from 5 μM to 50 μM for different SERCA isoforms. Paxilline exhibits significant anticonvulsant and neuroprotective effects, as well as certain antioxidant activity.

HY-100230A

ML133 hydrochloride	Inhibitor	99.82%
ML133 hydrochloride is a selective K_ir2 family channels inhibitor, with an IC₅₀ of 1.8 μM at pH 7.4 and 290 nM at pH 8.5.

HY-A0084

Procainamide hydrochloride	Activator	99.52%
Procainamide hydrochloride (Procaine amide hydrochloride) is a specific and potent inhibitor of DNA methyltransferase 1 (DNMT1), which reactivates the expression of tumor suppressor factors by demethylating tumor suppressor genes. Procainamide hydrochloride induces vacuolization in various cell types and reduces cell proliferation and migration. Procainamide hydrochloride relaxes airway smooth muscle by activating potassium channels. Procainamide hydrochloride can be used in cancer and arrhythmia research.

HY-P1275

Tertiapin-Q	Inhibitor	99.84%
Tertiapin-Q is a highly selective blocker of GIRK1/4 heterodimer and ROMK1 (Kir_1.1).

HY-117275

Meclofenamic acid	Inhibitor	99.66%
Meclofenamic acid (Meclofenamate) is a non-steroidal anti-inflammatory agent. Meclofenamic acid is a highly selective FTO (fat mass and obesity-associated) enzyme inhibitor. Meclofenamic acid competes with FTO binding for the m(6)A-containing nucleic acid. Meclofenamic acid is a non-selective gap-junction blocker. Meclofenamic acid inhibits hKv2.1 and hKv1.1, with IC₅₀ values of 56.0 and 155.9 μM, respectively.

HY-12343

ML277	Activator	98.46%
ML277 (CID-53347902) is a potent and selective activator of K(v)7.1 (KCNQ1) potassium channel activator (EC₅₀=270 nM), rescues function of pathophysiologically important mutant channel complexes in human induced pluripotent stem cell-derived cardiomyocytes.

HY-75839

Dronedarone Hydrochloride	Inhibitor	99.99%
Dronedarone Hydrochloride is a non-iodinated amiodarone derivative that inhibits Na⁺, K⁺ and Ca²⁺ currents.

HY-B1462

Chlorzoxazone	Activator	99.77%
Chlorzoxazone is a SK-type potassium channel activator. Chlorzoxazone modulates FOXO3 phosphorylation and Aβ. Chlorzoxazone enhances immunosuppression, attenuates vasoconstriction, attenuates cognitive deficits, and improves experimental autoimmune encephalomyelitis.

HY-B1302

Quinidine hydrochloride monohydrate	Inhibitor	99.97%
Quinidine hydrochloride monohydrate is an anti-arrythmic agent which is also a potent blocker of K⁺ channel with an IC₅₀ of 19.9 μM.

HY-N0466

Rebaudioside A	Inhibitor	98.0%
Rebaudioside A is a steviol glycoside with high sweetness potency and is a potent α-glucosidase inhibitor with an IC₅₀ value of 35.01 ug/mL. Rebaudioside A directly stimulates insulin secretion from pancreatic beta cells via inhibition of ATP-sensitive K⁺-channels.

HY-110105

NS8593 hydrochloride	Inhibitor	99.76%
NS8593 hydrochloride is a potent and selective small conductance Ca²⁺-activated K⁺ channels (SK channels) inhibitor. NS8593 hydrochloride reversibly inhibits SK3-mediated currents with a K_d value of 77 nM. NS8593 hydrochloride inhibits all the SK1-3 subtypes Ca²⁺-dependently (K_ds of 0.42, 0.60, and 0.73 μM, respectively, at 0.5 μM Ca²⁺), and does not affect the Ca²⁺-activated K⁺ channels of intermediate and large conductance (hIK and hBK channels, respectively).

HY-15416

NS309	Activator	99.09%
NS309 is a potent and selective activator of the Ca²⁺-activated SK/IK potassium channels, but displays no activity at BK channels.

HY-B1445

Minoxidil sulfate	Inhibitor	98.00%
Minoxidil sulfate, a potent and ATP-sensitive K⁺ channel opener, is the sulfated metabolite of minoxidil. Minoxidil sulfate is considered as a vasodilator to promote hair growth in vivo.

HY-Y0537E

Potassium chloride, for cell culture		99.80%
Potassium chloride, for cell culture is potassium chloride that can be used for cell culture. Potassium chloride, for cell culture increases extracellular potassium ion concentration to induce cellular depolarization, thereby activating voltage-gated calcium channels and regulating intracellular calcium signaling. Potassium chloride, for cell culture upregulates Brn-5. Potassium chloride, for cell culture inhibits the proliferation of neurons and some plant cells.

HY-N0221

Daurisoline	Inhibitor	99.90%
Daurisoline is a bis-benzylisoquinoline alkaloid that can be isolated from Menispermum dauricum and Rhizoma Menispermi. Daurisoline exerts a blocking effect on hERG and has antiarrhythmic effects. Daurisoline is a potent autophagy blocker that can be used for the research of cancer.

HY-110143

CLP257	Activator	99.31%
CLP257 is a selective K⁺-Cl cotransporter KCC2 activator with an EC₅₀ of 616 nM. CLP257 is inactive against NKCC1, GABAA receptors, KCC1, KCC3 or KCC4. CLP257 restores impaired Cl transport in neurons with diminished KCC2 activity. CLP257 alleviates hypersensitivity in rats with neuropathic pain. CLP257 modulates plasmalemmal KCC2 protein turnover post-translationally.

HY-113147

L-Palmitoylcarnitine	Inhibitor	99.88%
L-Palmitoylcarnitine, a long-chain acylcarnitine and a fatty acid metabolite, accumulates in the sarcolemma and deranges the membrane lipid environment during ischaemia. L-Palmitoylcarnitine inhibits K_ATP channel activity, without affecting the single channel conductance, through interaction with Kir6.2.

HY-19620A

Branaplam hydrochloride	Inhibitor	99.43%
Branaplam (LMI070; NVS-SM1) hydrochloride is a highly potent, selective and orally active survival motor neuron-2 (SMN2) splicing modulator with an EC₅₀ of 20 nM for SMN. Branaplam hydrochloride inhibits human-ether-a-go-go-related gene (hERG) with an IC₅₀ of 6.3 μM. Branaplam hydrochloride elevates full-length SMN protein and extends survival in a severe spinal muscular atrophy (SMA) mouse model.

Potassium Channel Compound Library

Compound library containing a variety of potassium channel inhibitors and activators.

289compounds HY-L119

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Potassium Channel

Potassium Channel

Potassium Channel Related Products (932)

Antibodies (6)

Related Compound Screening Libraries (1)

Potassium Channel Related Products (932):